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![]() Recently, my laboratory has made exciting discoveries regarding the molecular basis for both these types of errors ( Fagan et al., PNAS 2013 Fagan et al., RNA 2014 Maehigashi et al., PNAS 2014). When the ribosome reads a non-three nucleotide codon, this causes expression of aberrant or nonsense proteins, which are then targeted for degradation. Major types of errors resulting from ribosome dysregulation include mRNA frame reading and tRNA selection errors. Breakdown in translational fidelity of the ribosome is detrimental to cells due its central role in the production of all proteins in every living organism. Biological fitness is critically dependent upon the accurate flow of genetic information from DNA to RNA to protein.
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